Last edited by Malakinos
Saturday, April 25, 2020 | History

2 edition of Haemostatic mechanisms in vascular disease. found in the catalog.

Haemostatic mechanisms in vascular disease.

Jennifer Freeburn

Haemostatic mechanisms in vascular disease.

  • 41 Want to read
  • 3 Currently reading

Published by The Author] in [S.l .
Written in English


Edition Notes

Thesis (D. Phil.) - University of Ulster, 1996.

The Physical Object
Paginationv, 238p., tables :
Number of Pages238
ID Numbers
Open LibraryOL17176255M

Introduction to the Cardiovascular System. The cardiovascular system is sometimes called the blood-vascular, or simply the circulatory, consists of the heart, which is a muscular pumping device, and a closed system of vessels called arteries, veins, and the name implies, blood contained in the circulatory system is pumped by the heart around a .   Type 2 diabetes is characterized by a two- to fourfold increased risk of cardiovascular disease. This is generally attributed to the adverse effects of hyperglycemia and oxidative stress on vascular biology. It has also been shown that patients with prediabetic conditions, such as impaired fasting glucose and impaired glucose tolerance, are at increased risk of cardiovascular disease Cited by:


Share this book
You might also like
Sermons to young women

Sermons to young women

Consciousness & class.

Consciousness & class.

Paralegal guide to qualified pension plans under ERISA

Paralegal guide to qualified pension plans under ERISA

Oklahoma Panhandle

Oklahoma Panhandle

portable lexical analyzer writing system

portable lexical analyzer writing system

Geology of the country around Droitwich, Abberley and Kidderminster

Geology of the country around Droitwich, Abberley and Kidderminster

Cities of refuge

Cities of refuge

Moving

Moving

Nissen hut in war and peace.

Nissen hut in war and peace.

Ultra-high-sensitivity Mass Spectrometry with Accelerators (Royal Society Discussion Volumes)

Ultra-high-sensitivity Mass Spectrometry with Accelerators (Royal Society Discussion Volumes)

Turn it again

Turn it again

Microsoft Windows Xp Professional Step by Step Courseware Core

Microsoft Windows Xp Professional Step by Step Courseware Core

Haemostatic mechanisms in vascular disease. by Jennifer Freeburn Download PDF EPUB FB2

Numerous regulatory processes prevent widespread activation of coagulation, ensuring that blood remains fluid in the absence of vascular injury or other pathology. All components of the haemostatic process can be disturbed resulting in either a pro-thrombotic or bleeding tendency, and drugs that modify the haemostatic process are commonly used, particularly in patients with vascular disease.

Acute wounds normally heal in an orderly and efficient manner, and progress Haemostatic mechanisms in vascular disease. book through the four distinct, but overlapping phases of wound healing: haemostasis, inflammation, proliferation and remodelling (Figure ).1,2,3 In contrast, chronic wounds will similarly begin the healing process, but will have prolonged inflammatory, proliferative, or remodelling phases, Haemostatic mechanisms in vascular disease.

book by: 1. Book Info Mechanisms of Vascular Disease. Book Description: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

INTRODUCTION. Acute wounds normally heal in an orderly and efficient manner, and progress smoothly through the Haemostatic mechanisms in vascular disease. book distinct, but overlapping phases of wound healing: haemostasis, inflammation, proliferation and remodelling (Figure ). In contrast, chronic wounds will similarly begin the healing process, but will have prolonged inflammatory, proliferative, or remodelling Cited by: 1.

to disordered haemostatic mechanisms in the pathogenesis of vascular disease in non-diabetics,2 and such disorders may be of Haemostatic mechanisms in vascular disease. book importance in determining the increased risk ofboth large-vessel and small-vessel disease in Haemostatic mechanisms in vascular disease.

book Evidence of an "increased thrombotic tendency" in diabetes would have aetiological, preventive, and Cited by: Various mechanisms, including endothelial cell nitric oxide and prostacyclin, promote blood fluidity by preventing platelet aggregation and dilating intact blood vessels.

These mediators are no longer produced when the Haemostatic mechanisms in vascular disease. book endothelium is disrupted. Under these conditions, platelets adhere to the damaged intima and form aggregates.

Figure 1. Summary of Factors Maintaining Vascular Homeostasis. Adequate blood flow, blood pressure, distribution, and perfusion involve autoregulatory, neural, and endocrine mechanisms.

Neural Regulation. The nervous system plays a critical role in the regulation of vascular homeostasis. Three homeostatic mechanisms ensure adequate blood flow, blood pressure, distribution, and ultimately perfusion: neural, endocrine, and autoregulatory mechanisms. They are summarized in Figure 1.

Figure 1. Adequate blood flow, blood pressure, distribution, and perfusion involve autoregulatory, neural, and endocrine mechanisms. Mechanisms of Hemostasis Maureane Hoffman Professor of Pathology Duke University Medical Center Path & Lab Medicine Service Durham VAMC [email protected] x email- [email protected] she is Haemostatic mechanisms in vascular disease.

book clinical pathologist - she does blood banking/ laboratory hematology, in case you were wondering. A valuable study of the science behind the medicine, Muscle: Fundamental Biology and Mechanisms of Disease brings together key leaders in muscle biology.

These experts provide state-of-the-art insights into the three forms of muscle--cardiac, skeletal, and smooth--from molecular anatomy, basic physiology, disease mechanisms, and targets of therapy. Mechanisms of Vascular Disease: A Textbook for Vascular Specialists comprehensively covers a variety of common and unusual pathophysiologies encountered in vascular surgery, and is an ideal resource for both the trainee, and practicing clinical vascular surgeon seeking an up-to-date resource on the topic.

Mechanisms of Vascular Disease: A Reference Book for Vascular Specialists. edited by Robert Fitridge and Matthew Thompson.

$ | | Paperback | | pp. FREE | | Ebook (pdf) | | pp. The well-acknowledged interplay between autophagy and lipid metabolism may help to maintain homeostasis of lipid metabolism. Targeting autophagy to maintain lipid homeostasis offers a focal point for novel therapy and management of cardiometabolic diseases, as autophagy can be regulated with pharmacological or natural agents.

In spite of the abundance of epidemiological evidence that links cigarette smoking to vascular disease, the pathologic mechanisms for such interaction are not clear.

The endothelium is a major target organ that undergoes activation when exposed to common vascular triggers, including hypertension, hypercholesterolemia, hyperglycaemia and smoking. Hemostasis is maintained in the body via three mechanisms: Vascular spasm (Vasoconstriction) - Vasoconstriction is produced by vascular smooth muscle cells, and is the blood vessel's first response to injury.

The smooth muscle cells are controlled by vascular endothelium, which releases intravascular signals to control the contracting properties. This textbook provides an up-to-date account of the mechanisms and pathophysiology of vascular disease, and the current treatment options open to vascular surgeons.

As the scientific basis of vascular disease advances rapidly, it is critical that clinicians have access to relevant information written specifically for vascular surgeons.5/5(1). While disease is often a result of infection or injury, most diseases involve the disruption of normal homeostasis.

Anything that prevents positive or negative feedback from working correctly could lead to disease if the mechanisms of disruption become strong enough. Aging is a general example of disease as a result of homeostatic imbalance.

Homeostatic regulation involves three parts or mechanisms: 1) the receptor, 2) the control center and 3) the effector. The receptor receives information that something in the environment is changing. The control center or integration center receives and processes information from the receptor.

Vascular calcification (VC), which is categorized by intimal and medial calcification, depending on the site(s) involved within the vessel, is closely related to cardiovascular disease. Specifically, medial calcification is prevalent in certain medical situations, including chronic kidney disease and diabetes.

The past few decades have seen extensive research into VC, revealing that the. The vascular system is responsive to changes within both the vascular wall and target organs through the action of local factors that influence its structure and function.

In this chapter, we review the anatomic and functional properties of the vasculature, with particular reference to the maintenance of vascular by: 2. The fact that the vascular manifestations consistently precede tissue fibrosis suggests that endothelial cells (ECs) are the primary target in this disease, and that ECs interaction with other cells and pathways, including the innate and adaptive immune system, platelets and coagulation factors, smooth muscle cells, and fibroblasts underlie the Cited by: 8.

New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes. To send content items to your account, please Author: Robert Fitridge, Matthew Thompson.

Intercellular communication between vascular smooth muscle cells (VSMCs) and endothelial cells (ECs) is essential for the maintenance of vascular homeostasis. The presence of exosomes, a recently discovered player in vascular cell communication, has been associated with vascular disease : Jeongyeon Heo, Hee Cheol Yang, Won Jong Rhee, Hara Kang.

Vascular smooth muscle cells (SMCs) and monocytes/macrophages represent major players in atherosclerotic vascular diseases. In addition to physiological and pathological roles of each cell type in atherosclerosis, dynamic interplay between SMCs and monocytes/macrophages may contribute to the pathogenesis of atherosclerosis more critically than previously by: 2.

Request PDF | Vascular Disease and the Skeleton | This chapter briefly relates the vital interplay between vascular biology and bone physiology as relevant to metabolic bone disease. It. Epelman, S. et al. Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation.

Immun Cited by: The role of the cardiovascular system in maintaining homeostasis is pretty extensive. If our heart ever stopped pumping blood, even if it was for only half of a minute, significant damage would've been done.

The simple fact that our heart continues to pump blood is an clear-cut example of homeostasis. Following injury, vascular constriction reduces bleeding, and allows time to initiate haemostasis.

With large volume haemorrhage, resulting systemic hypotension is an important physiological mechanism to minimise blood loss and facilitate stabilisation of the haemostatic plug. MicroRNAs in endothelial cell homeostasis and vascular disease Article in Current Opinion in Hematology 25(3):1 March with 40 Reads How we measure 'reads'.

Labile Zn may mediate important downstream actions of NO including vascular cytoprotection and vasodilation. Several vascular disease risk factors (including aging, smoking and diabetes) interfere with Zn homeostatic mechanisms and both hypozincaemia and Zn transporter protein abnormalities are linked to atherosclerosis and microvascular : P.

Zalewski, J. Beltrame, A. Wawer, A. Abdo, C. Murgia. Define haemostatic. haemostatic synonyms, haemostatic pronunciation, haemostatic translation, English dictionary definition of haemostatic. or adj 1. retarding or stopping the flow of blood within the blood vessels 2.

retarding or stopping bleeding n a. A discussion of progress in macrophage biology, examining their classification, diverse lineages, identities and regulation, their roles in regulating normal physiology and development, and their Cited by: Under common practice, recognition and treatment of type 2 diabetic nephropathy (DN) are usually revealed at a rather late stage (CKD stages 3–5) due to the insensitiveness of available diagnostic markers.

Accumulating data obtained from vascular homeostasis in late stage DN demonstrated (1) a defective angiogenesis and impaired NO production which explains the Cited by: Cigarette smoking plays a major role in the development of atherosclerosis and is associated with increased morbidity and mortality for coronary heart disease, stroke and peripheral vascular disease.

In spite of the abundance of epidemiological evidence that links cigarette smoking to vascular disease, the pathologic mechanisms for such Cited by: For example, population studies demonstrate that K + intake is inversely associated with blood pressure and cardiovascular disease even more than high Na + intake.

In their review, McDonough and Youn discuss the molecular mechanisms involved in K + homeostasis and how multiple systems interface to accomplish K + : Gary C. Sieck. Inside Ultrasound Vascular Reference Guide The complete guide to vascular disease, noninvasive testing, and interpretation.; Chapters include fluid dynamics, vascular disease, anatomy, physiology, testing and optimization, measurements and calculations, worksheets, report examples, pharmacology, extensive references, and cardiac effects on spectral Doppler/5(25).

It reviews data that highlight how prevalent vascular disease processes impair skeletal homeostatic mechanisms. Avascular necrosis (AVN), or osteonecrosis, represents the best-recognized clinical disorder of vascular disease and the : Dwight A.

Towler. Homeostasis is the activity of cells throughout the body to maintain the physiological state within a narrow range that is compatible with life. Homeostasis is regulated by negative feedback loops and, much less frequently, by positive feedback loops.

Both have the same components of a stimulus, sensor, control center, and effector; however. Microarray studies have shown an altered profile of miRs expression in subjects with type 2 diabetes. 67–69 Indeed, diabetic patients display a significant deregulation of miRs involved in angiogenesis, vascular repair, and endothelial homeostasis.

67 Over the last few years, different studies have explored the mechanisms whereby deregulation Cited by:   In Brief The pathophysiology of the link between diabetes and cardiovascular disease (CVD) is complex and multifactorial. Understanding these profound mechanisms of disease can help clinicians identify and treat CVD in patients with diabetes, as well as help patients prevent these potentially devastating complications.

This article reviews the biological Cited by:. Many molecular and cellular mechanisms link inflammation and haemostatic mechanisms.

Inflammation, and perhaps chronic pdf, may play important roles in the initiation and progression of atherosclerosis. Atherosclerotic lesions are heavily infiltrated by cellular components associated with inflammation (macrophages and T lymphocytes), and Cited by: Peripheral vascular disease often stems from large risk factors comprised of cigarette smoking, diabetes, high blood pressure and high blood cholesterol [3].

Inthere were approximately million people affected by peripheral vascular disease [3]. Inthis disease resulted in approximat deaths [4].Get this from a library! Mechanisms of Vascular Disease: a Ebook Book for Vascular Specialists.

[Robert Fitridge (Ed); Matthew Thompson] -- New, updated edition first published with Cambridge University Press.

This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics.